Synthesis of New Oxopyrimidine and Cyanopyridine Derivatives Containing the Pyrimidine Benzothiazole Moiety with the Evaluating their Colon Anticancer Bioactivity

In this contribution, new derivatives of bicyclic fused rings with bridgehead nitrogen 3-substituted imidazo/pyrimidine A1-A3 were synthesized by reacting 2-aminobenzothiazol, acetyl acetone, and different substituted aldehydes in a one-pot reaction. These compounds then condensed 4-bromobenzaldehyde 4-(N,N-dimethylamino)benzaldehyde to form chalcone A4-A9. Ring closure these A4-A9 urea malononitrile afforded oxopyrimidine A10-A15 cyanopyridine A16-A21, respectively. characterized FT-IR, 1H NMR, 13C NMR spectroscopy. The second part work included some the important applications conducted for evaluate their biological activities against colon cancer, which showed excellent results disease.